Antone L. Brooks
Professor of Radiation Toxicology
"Optimizing the Scientific Regulatory and Societal Impact of the DOE Low Dose Research Program" Priniciple Investigator

Expertise: Radiation Ecology Cytogenetics Health Effects of Radiation Internally-deposited radiation Cancer radiation Public Outreach Low Dose Radiation Risk

Contact Information: Antone L. Brooks Washington State University TriCities Richland, Washington 99352-1671 Phone: 509-372-7550 Fax: 509-372-7552 E-mail: brooks@tricity.wsu.edu

Antone L. Brooks, PhD

EDUCATION

Institution and Location, Degree,Year, Field of Study:

• University of Utah, Salt Lake City, Utah B.S. 1961 Experimental Biology
• University of Utah, Salt Lake City, Utah M.S. 1963 Radiation Ecology
• Cornell University, Ithaca, New York Ph.D. 1967 Physical Biology

EXPERIENCE

DOE-OBER
"Optimizing the Scientific Regulatory and Societal Impact of the DOE Low Dose Research Program" Priniciple Investigator, 1999 - present

Washington State University-Tricities Professor 1999-present
Environmental Science Department
Richland, Washington

Washington State University-Tricities Senior Scientist 1996-1999
Environmental Science Department
Richland, Washington

Battelle, Pacific Northwest National Laboratory Senior Scientist 1995-1996
Decision, Safety and Risk Management Group
Richland, Washington

Battelle, Pacific Northwest National Laboratory Section Manager 1989-1995
Cellular and Mammalian Biology Section
Richland, Washington

Lovelace Inhalation Toxicology Research Institute Group Leader 1979-1989
Cellular and Molecular Toxicology Group
Albuquerque, New Mexico

U.S. Department of Energy Technical 1977-1979
Office of Health and Environmental Research Representative
Washington D.C.

Lovelace Inhalation Toxicology Research Institute Research Scientist 1966-1977
Albuquerque, New Mexico

Cornell University NIH Pre-doctoral Fellow 1963-1966
Department of Physical Biology
Ithaca, New York

MEMBERSHIPS

Member, "National Council on Radiation Protection and Measurements (NCRP)" 1980-Present.

Member, Science Advisory Council, "International Consortium for Health Effects of Ionizing Radiation (ICRHER)" 1995-Present.

Member, National Academy of Sciences Committee, "Biological Effects of Ionizing Radiation (BEIR VI)" 1993-1998.

Member, National Institute of Health, "Cancer-Biology-Immunology Contract Review Committee" 1989-1998.

Co-Chairman, NCRP Task group 10, "Liver Cancer Risk from Internal Emitters" 1980-Present.

Member, Editorial Board, International Journal of Radiation Biology,1997-Present.

Expert Reviewer for NIH, DOE and NASA for radiation research funding.1998-Present.

Elected, Biology Councilor for Radiation Research Society, 2002-2005.

Board of Directors NCRP, Vice President Program Area Comittee 1, Basic Criteria, Epidemiology, Radiobiology, and Risk, 2005 - Present.

Environmental Protection Agency Radiation Advisory Council, 2005-Present.

PRESENTATIONS (click to open list of presentations along with powerpoint presentations)

PUBLICATIONS OF ANTONE L. BROOKS

Brooks, A.L. (1963) Comparative radiation ecology of six Utah dairy farms. Master's Thesis, University of Utah, Salt Lake City, Utah.

Pendleton, R.C., Mays, C.W., Lloyd, R.D., and Brooks, A.L. (1963) Differential accumulation of I131 from local fallout in people and milk. Health Physics, 9:1253-1262.

Brooks, A.L. (1967) Induction and repair of chromatid deletions in the testes and bone marrow of the Chinese hamster. PhD. Thesis, Cornell University, Ithaca, New York.

Brooks A.L. and Lengermann, F.W. (1967) Comparison of radiation-induced chromatid aberrations in the testes and bone marrow of the Chinese hamster. Radiat. Res. 32:587-595.

Jones, R.K., Brooks, A.L., Ferris, A.C. and Thomas, R.G. (1967) Occurrence of chloroluekemia in Holtzman rats exposed to a soluble aerosol of 90 Sr. In: Effects of internal emitters. University of Utah, Salt Lake City, Utah.

Brooks A.L. and Lengermann, F.W. (1968) Determining the repair rate for radiation-induced chromatid deletions during the first 24 hours after irradiation. Radiat. Res. 38:181-192.

Brooks, A.L.and McClellan, R.O. (1968) Cytogenic effects of strontium-90 on the bone marrow of the Chinese hamster. Nature 219:761-763.

Brooks, A.L and McClellan, R.O. (1969) Chromosome aberrations and other effects produced by 90SR-90Y in Chinese hamsters. Int. J. Radiat. Biol. 16:545-561.

Brooks, A.L. and Mead, D.K. (1969) The metaphase chromosomes of Chinese hamster liver cells following partial hepatectomy. Can. J. Genet. Cytol. 11:794-798.

Jones, R.K., Brooks, A.L., Ferris, A.C., and Shaffer, D.K. (1970) Transferable 90Sr-induced leukemia in Holtzman rats. In: Myeloproliferative disorders of animals and man. W.J. Clarke, B.E. Howard and P.L. Hackett (eds.). Proceedings of the Eighth Hanford Symposium, May 20-23, 1968, Richland, Washington, CONF-680529, NTIS, Springfield, Virginia, pp. 517-532.

Sturbaum, B., Brooks, A.L., McClellan, R.O. (1970) Tissue distribution and dosimetry of 144Ce in Chinese hamsters. Radiat. Res. 44, 359-367.

Brooks, A.L., R.F. Peters, M.D. Rollag (1971) Metaphase chromosome aberrations in Chinese hamster liver cells in vivo after Single acute 60-Co Exposure.Radiat. Res. 45, 191-201.

Brooks, A.L., McClellan, R.O., McKay, L.R. (1971) Comparison of the relative biological effectiveness of 241Am and 144Ce on the production of chromosolme aberrations in Chinese hamster liver. In: Proceedings of the Health Physics Society Midyear Topical Symposium, November 3-6, 1970, Idaho Falls, Idaho, pp. 600-618.

Brooks, A.L., D.K. Mead, and R.F. Peters (1971) Effects of chronic exposure to 60Co on the frequency of metaphase chromosome aberrations in the liver cells of the Chinese hamster (in vivo) Int. J. Radiat. Biol. 20, 599-604.

Brooks, A.L., R.O. McClellan, and S.A. Benjamin (1972) The effects of 144Ce-144Pr on the metaphase chromosomes of the Chinese Hamster liver cells in vivo. Radiat. Res. 52, 481-498.

Brooks, A.L., Mewhinny, J.A., and McClellan, R.O. (1972) The in vivo cytogenetic effects of 252Cf on liver and bone marrow of the Chinese hamster. Health Phys. 22:701-706.

McKay, L.R., Brooks, A. L., McClellan, R.0. (1972) The retention, distribution, dose and cytogenetic effects of 241Am citrate in the Chinese hamster. Health Phys. 22:633-640.

Mewhinney, J.A., Brooks, A.L., and McClellan, R.O. (1972) Comparison of the retention and distribution of injected 252Cf in rats and Chinese hamsters. Health Physics 22:695-700.

Brooks, A.L., D.K. Mead, R.F. Peters (1973), Effect of aging on the frequency of metaphase chromosome aberrations in the liver of the Chinese hamster. Journal of Gerontology 28(4):452-454.

Brooks, A.L., Benjamin, S.A., and McClellan, R.O. (1974). Toxicity of 90Sr-90Y in Chinese hamsters. Radiat. Res. 57:71-481.

Brooks, A.L., Retheford, J.C., McClellan, R.0. (1974) Effect of 239PuO2; particle number and size on the frequency and distribution of chromosome aberrations in the liver of the Chinese hamster. Radiat. Res. 59, 693-709.

McKay, L.R., Shaw, S.M., Brooks, A.L. (1974) Metaphase chromosome aberrations
the Chinese hamster liver in vivo after either acute or fractionated 60CO Irradiation. Radiat. Res. 57, 187-194.

Brooks, A.L. (1975) Chromosome damage in liver cells from low dose rate alpha, beta and gamma irradiation: Derivation of RBE. Science 190, 1090-1092.

Snipes, M.B., Brooks, A.L., Cuddihy, R.G., McClellan, R.O. (1975) Review of John Gofman's paper on lung cancer hazard from inhaled plutonium. ERDA Research and Development Report, LF-51, NTIS, Springfield, Virginia.

Benjamin, S.A., Brooks, A.L., Jones, R.K. (1975) Effect of pulmonary irradiation from internal emitters on the transformation and kinetics of canine lymphocytes in vitro. In: The cell cycle in malignancy and immunity, J.C. Hampton (ed.). Proceedings of the 13th Hanford Biology Symposium, October 1-3, 1973, Richland, Washington. CONF-731005, NTIS, Springfield, Virginia, pp. 224-238.

Benjamin, S.A., Brooks, A.L., Cuddihy, R.G., McClellan, R.O. (1976) Biological effectiveness of 239Pu, 144Ce, 90Sr citrate in producing chromosome damage, bone-related tumors and life shortening in the Chinese hamster. In: Biological and environmental effects of low-level radiation. IAEA, Vienna Austria, pp. 143-152.

Brooks, A.L., McClellan, R.O. (1976) Changes in chromosome aberration frequency in Chinese hamster liver related to LET and microdose distribution. In: Health effects of plutonium and radium. Webster S.S. Jee (ed.). J.W. Press, Salt Lake City, Utah, pp. 767-778.

Brooks, A.L., LaBauve, R.J., McClellan, R.O., Jensen, D.A. (1976) Chromosome aberration frequency in blood lymphocytes of animals with 239Pu lung burdens. In: Radiation and the lymphatic system, J.E. Ballou (ed.). Proceedings of the 14th Hanford Biology Symposium, September 30-October 2, 1974, Richland, Washington, CONF-740930, NTIS, Springfield, VA, pp. 106-112.

Brooks, A.L., Carsten, A.L., Mead, D.K., Retherford, J.C. (1976) The effects of continuous intake of tritiated water (HTO) on the liver chromosomes of mice. Radiat. Research 68, 480-489.

Brooks, A.L., McClellan, R.O., Peters, R.F., Mead, D.K. (1976) Effect of size and alpha flux of 239PuO2 particles on production of chromosome aberrations in liver of Chinese hamster. In: Biological and rnvironmental effects of low-level radiation. IAEA, Vienna, Austria.

Benjamin, S.A., and Brooks, A.L. (1977). Spontaneous Lesions in Chinese Hamsters. Vet. Pathology. 14:449-462.

Miglio, J.J., Muggenburg, B.A., and Brooks, A.L. (1977) A rapid method for determining the relative solubility of plutonium aerosols. Health Physics. 33:449-457.

Brooks, A.L., Diel, J.H., and McClellan, R.O. (1979) The influence of testicular microanatomy on the potential genetic dose from internally deposited 239Pu citrate in Chinese hamster, Mouse and Man. Radiat. Res. 77, 292-302.

Brooks, A.L. (1980) Low dose and low dose-rate effects on cytogenetics, In: Radiation biology in cancer research, R.E. Meyn and H.R. Withers (eds.). Raven Press, New York, pp. 263-276.

LaBauve, R.J., Brooks, A.L., Mauderly, J.L., Hahn, F.F., Redman, H.C., Macken, C., Slauson, D.O., MeWhinney, J.A., and McClellan, R.O. (1980) Cytogenetic and other biological effects of 239Pu02 inhaled by Rhesus monkey. Radiat. Res. 82, 310-335.

Brownstein, D.G., Brooks, A.L. (1980) Spontaneous endomyometrial neoplasms in aging Chinese hamsters. J. Natl. Cancer Instit. 64, 1209-1214.

Brooks, A.L., Wolff, R.K., Royer, R.E., Clark, C.R., Sanchez, A., McClellan, R.O. (1980) Biological availability of mutagenic chemicals associated with diesal exhaust particles. In: Health effects of diesel engine emissions, W.E. Pepelko, R.M. Danner, N.A. Clarke (eds.). EPA-600/9.80057a, pp. 345-358.

Clark, C.R., Royer, R.E., Brooks, A.L., McClellan, R.O., Marshall, W.F., Naman, T.M., Seizinger, D.E. (1981) Mutagenicity of diesel exhaust particle extracts: Influence of car type. Fundam. Appl. Toxicol. 1:260-265.

Brooks, A.L., Wolff, R.K., Royer, R.E., Clark, C.R., Sanchez, A., McClellan, R.O. (1981) Deposition and biological availability of diesel particles and their associated mutagenic chemicals. Environ. Int. 5:263-267.

Griffis, L.C., Snipes, M.B., Brooks, A.L. (1981) Clearance by the rat of inhaled fly ash from fluidized bed coal combustion. J. Toxicol. Environ. Health 7:117-124.

Quayle, S.S., Brooks, A.L. (1981) Influence of driving cycle, fuel type and oxidation catalyst on fuel economy, emissions and mutagenic activity of diesel particles. In: Eighteenth Summary Report, Automative Technology Development Contractor's Coordination Meeting, CONF-801182, NTIS Springfield, VA, pp. 285-291.

Brooks, A.L., Benjamin, S.A., Jones, R.K., McClellan, R.0. (1982) Interaction of 144Ce and partial hepatectomy in the production of liver neoplasms in the Chinese hamster. Radiat. Res. 91, 573-588.

Clark, C.R., Dutcher, J.S., Brooks, A.L., McClellan, R.O., Marshall, W.F., Naman, T.M. (1982) Mutagenicity of diesel exhaust particle extracts: Influence of driving cycle and environmental temperature.Fund. Applied Toxicol. 2, 153-157.

Clark, C.R., Henderson, T.R., Royer, R.E., Brooks, A.L., McClellan, R.O., Marshall, W.F., Naman, T.M. (1982) Mutagenicity of diesel exhaust particle extracts: Influence of fuel composition in two diesel engines. Fund. Applied Toxicol. 2:38-43.

Li, A.P., Royer, R.E., Brooks, A.L., and McClellen, R.O. (1982) Cytotoxicity of diesel exhaust particle extracts-A comparison among five diesel passenger cars of different manufactures. Toxicology 24:1-8.

Marshall, T.C, Royer, R.E., Li, A.P., Kusewill, D.F., Brooks, A.L. (1982) Acute and genetic toxicity of 1-Nitropyrene and its fate after single oral doses to rats. J. of Tox and Environ Health, 10:373-384.

McClellan, R.O., A.L. Brooks, R.G. Cuddihy, R.K. Jones, J.L. Mauderly, R.K. Wolff (1982) Inhalation toxicology of diesel exhaust particles, In: Toxicological effects of emissions from diesel engines, J.E. Lewtas (ed.). Elsevier Science Publishing Co., pp. 99-120.

Brooks, A.L. (1982) Cytogenetic studies of lung cells following inhalation of fly ash, chemical mutagens and effluents from power-related industry. DOE Research and Development Report, LMF-100, NTIS, Springfield, VA.

Carsten, A.L., Brooks, A.L., Commerford, S.L., Cronkite, E.P. (1982) Genetic and somatic effects in animals maintained on tritiated water (special considerations of tritium distribution, turnover and microdosimetry) In: Proceedings of the Workshop on Tritium Radiobiology and Health Physics, H. Matsudaira, T. Yamaguchi, Nakasawa, T., Salto, C. (eds.), National Institute of Radiological Sciences, Tokyo, Japan (NIRS-M-41) and Associated Universities, Inc., Brookhaven National Laboratory, Long Island, New York (BNL-30230).

Li, A.P., Brooks, A.L. (1982) Use of Chinese hamster ovary cells in evaluating potential hazards from energy effluents: Application to diesel exhaust emissions. In: Health impacts of different sources of energy. IAEA-SM-254/58, IAEA Vienna, Austria, pp. 430-435.

Brooks, A.L., Benjamin, S.A., Hahn, F.F., Brownstein, D.G., Griffith, M.W., McClellan, R.0. (1983). The induction of liver tumors by 239Pu citrate or 239PuO2 particles in the Chinese hamster. Radiat. Res. 96, 135-151.

Brooks, A.L., Redman, H.C., Hahn, F.F., Brownstein, D.G., Griffith, W.C., McClellan, R.O. (1983) The retention, distribution, dose and cytogenetic effects of inhaled 239Pu02 or 239Pu(NO3)4 in non-human primates. In: Somatic and genetic effects, Broerse, J.J., Barendsen, G.W., Kal, H.B., Van der Kogel, A.J. (eds.). Martins Nijhoff, Amsterdam, The Netherlands, pp. B4-04-Ba4-05.

Allsup, J.R., Seizinger, D.E., Cox, F.W., Brooks, A.L., McClellan, R.O. (1983) Vehicle emission characteristics using mechanically emulsified alcohol/diesel fuels. DOE Research and Development Report, DOE/BETC/RI-83/4, NTIS, Springfield, VA.

Li, A.P., A.L. Brooks, C.R. Clark, R.W. Shimizu, R.L. Hanson, J.S. Dutcher (1983), Mutagenicity testing of complex environmental mixutures with Chinese hamster ovary cells, In: Short-term bioassays in the analysis of complex environmental mixtures III. Waters, Sandhu, Lewtas, Claston, Chernoff, Nesnow (eds.). Plenum Publishing Corporation, pp. 183-196.

Li, A.P., Hahn, F.F., Zamora, P.O., Shimizu, R.N., Henderson, R.F., Brooks, A.L., and Richards, R. (1983) Characterization of a lung epithelial cell strain with potential application in toxicological studies. Toxicology 27, 257-272

Zamora, P.O., Gregory, R.E., Brooks, A.L. (1983) In vitro evaluation of the tumor-promoting potential of diesel-exhaust-particle extracts. Journal of Environment and Toxicological Health, 11:187-197.

Zamora, P.O., Benson, J.M., Li, A.P., Brooks, A.L. (1983) Evaluation of an exposure system using cells grown on collagen gels for detecting highly volatile mutagens in the CHO/HGPRT mutation assay.Environmental Mutagenesis 5, 795-801.

Zamora, P.O., Benson, J.M., Marshall, T.C., Mokler, B.V., Li, A.P., Dahl, A.R., Brooks, A.L., McClellan, R.O. (1983) Cytotoxicity and mutagenecity of vapor-phase pollutants in rat lung epithelial cells and Chinese hamster ovary cells grown on collagen gels. Journal of Toxicology and Environmental Health 12:27-38.

Brooks, A.L., Li, A.P., Dutcher, J.S., Clark, C.R., Rothenberg, S.J., Kiyoura, R., Bechtold, W.E. and McClellan, R.O. (1984) A comparison of genotoxicity of automotive exhaust particles from laboratory and environmental sources. Environmental Mutagenesis 6, 651-668.

Brooks, A.L., Shimizu, R.W., Li, A.P., Benson, J.M., Dutcher, J.S. (1984) The induction of sister chromatid exchanges by environmental pollutants: Relationship of SCE to other measures of genetic damage. In: Sister chromatid exchanges, R.R. Tice and A. Hollaender (eds.). Plenum Publishing, New York, pp. 385-396.

Muggenburg, B.A., Brooks, A.L., Hahn, F.F., Boecker, B.B., McClellan, R.0. (1984) Species comparison of liver cancers induced by internally deposited 144Ce or 239Pu in dogs and Chinese hamsters. (Meeting Abstract) Thirty-Second Annual Meeting of the Radiation Research Society, p. 78.

Shimizu, R.W., Benson, J.M., Li, A.P., Henderson, R.F., Brooks, A.L. (1984) Evaluation of the genotoxicity of process stream extracts from a coal gasification system. Environ. Mutag 6, 825-834.

Shimizu, R.W., J.D. Sun, A.P. Li, G.J. Newton, A.L. Brooks (1984) The use of sister-chromatid exchange in Chinese hamster primary lung cell cultures to measure genotoxicity. Mutation Research 130, 333-341.

Bechtold, W.E., J.S. Dutcher, A.L. Brooks, T.R. Henderson (1985) Fractionation of diesel particle extracts by sephadex LH-20 and Thin-layer chromatography, J Applied Toxicol 5, 295-300.

Bechtold, W.E., J.S. Dutcher, A.L. Brooks, R.F. Henderson (1985) Contribution of primary aromatic amines to the mutagenicity of gasifier tars and coal oils.Mutation Res. 155, 7-16.

Benson, J.M., A.L. Brooks, Y.S. Cheng, R.F. Henderson, and J.E. White. (1985) Environmental transformation of 1-nitropyrene on glass surfaces.Atmospheric Environment 19(7):1169-1174.

Hanson, R.L., A.R. Dahl, S.J. Rothenberg, J.M. Benson, A.L. Brooks (1985) Chemical and biological characterization of volatile components of environmental samples after fractionation by vacuum line cryogenic distillation.Arch. Environ. Contam. Toxicol. 14, 289-297.

Seizinger, D.E., Marshall, W.F., and Brooks, A.L. (1985) Fuel influences on diesel particulate. SAE Technical Paper Series, #850546, ISSN0148-7191, Society of Automotive Engineers, Warrendale, Pennsylvania.

Shami, S.G., Wolff, R.K., Hahn, F.F., Griffith, W.C., and Brooks, A.L. (1985) Early cytokinetic and morphological response of rat lungs to inhaled benzo(a)pyrene, gallium oxide and SO2. Environ Res. 37(1):12-25.

Bechtold, W.E., T.R. Henderson, A.L. Brooks (1986) Isolation, identification and bactyerial mutagenicity of 2-nitro-9-fluorenone from diesel-exhaust particle extracts. Mutation Res 173, 105-109.

Benson, J.M., Brooks, A.L., Cheng, Y.S., Henderson, T.R., White, J.E. (1986) Environmental transformation of 1-nitropyrene in glass surfaces. In: Polynuclear aromatic hydrocarbons, M. Cooke, and A.J. Dennis (eds.). Battelle Press, Columbus, Ohio, pp. 77-86.

Brooks, A.L. (1986) Whole animal and in vivo cell systems for detecting mutations. In: Safety evaluation of drugs and chemicals, W.E. Floyd (ed.), Chapter 12. Hemisphere Publishing, New York, New York, pp. 167-185.

Brooks, A.L., Guilmette, R.A., Evans, M.J., Diel, J.H. (1986) The induction of chromosome aberrations in the liver of Chinese hamsters by injected Thorotrast. In The radiobiology of radium and thorotrast, W. GØssner, G.B. Gerber, U. Hagen, and A. Luz, (eds.). Urban and Scwarzemberg, Mônchen, pp. 197-201.

Brooks, A.L., Guilmette, R.A, Hahn, F.F., and Jirtle, R.L. (1986) Uptake and clearance of plutonium-238 from liver cells transplanted into fat pads of F344 rats. Int. J. Radiat. Bio. 50:631-639.

Zamora, P.O., R.E. Gregory, A.P. Li, and A.L. Brooks (1986) An in vitro model for the exposure of lung alveolar epithelial cells to toxic gases. JEPTO 7, 159-168.

Benson, J.M., Brooks, A.L., Cheng, Y.S., Henderson, T.R., White, J.E. (1987)
Environmental transformation of polycyclic aromatic hydrocarbons on glass surfaces. In: Health and environmental research on complex organic mixtures. R.H. Gray, E.K. Chess, P.J. Mellinger, R.G. Riley, and D.L. Springer, (eds.). Proceedings of the 24th Hanford Life Sciences Symposium, October 20-24, 1985, Richland, Washington. CONF-851027, NTIS, Springfield, VA, pp. 281-292.

Brooks, A.L., D.E. Seizinger (1987) Potential interactions between different chemical fractions from diesel-exhaust extracts in the production of mlutations, In: Health and environmental research on complex organic mixtures, R.H. Gray, E.K. Cress, P.J. Mellinger, R.G. Riley, D.L. Springer, (eds.). Proceedings of the 24th Hanford Life Sciences Symposium, October 20-24, 1985, Richland, Washington. CONF-851027, UC-11,41, NTIS, Springfield, VA, pp. 259-269.

Hahn, F.F., Brooks, A.L., and Mewhinney, J.A. (1987) A primary pulmonary sarcoma in a Rhesus monkey after inhalation of plutonium dioxide. Radiation Research, 112:391-397.

Bender, M.A., A.A. Awa, A.L. Brooks, H.J. Evans, P.G. Groer, L.G. Littlefield, C. Perira, R.J. Preston, B.W. Wachholz (1988) Current status of cytogenetic procedures to detect and quantify previous exposures to radiation. Mutation Res. 196, 103-159.

Brooks, A.L., S.W. Jordan, K.K. Bose, J. Smith, D.C. Allison (1988) The cytogenetic and hepatotoxic effects of dioxin on mouse liver cells. Cell Biology and Toxicology 4, 31-39.

Kitchin, R.M., W.E. Bechtold, A.L. Brooks (1988) The structure-function relationships of nitrofluorenes and nitrofluorenones in the Salmonella mutagenicity and CHO sister-chromatid exchange assays. Mutat. Res. 206:367-377.

Brooks, A.L., W.C. Griffith, N.F. Johnson, G.L. Finch, and R.G. Cuddihy (1989) The induction of chromosome damage in CHO cells by beryllium and radiation given alone and in combination. Radiat. Res. 120, 494-507.

Brooks, A.L. and W.C. Griffith (1989) Chromosomal binding and clearance of benzo(a)pyrene-diol-epoxide. In: Multilevel health effects research: From molecules to man, Proceedings of the 27th Hanford Symposium on Health and the Environment, J.F. Park and R.A. Pelroy (eds.). Battelle Press, Columbus, Richland, pp. 307-312.

Brooks, A.L., R.L. Hanson, F.A. Seiler, and R.F. Henderson (1989) In vitro genotoxicity of dyes present in colored smoke munitions. Environ. Mol. Mutagen. 13:304-314.

Finch, G.L., Brooks, A.L., Hoover, M.D., Cuddihy, R.G. (1989) Influence of physiochemical properties of beryllium particles on toxicity to cultured cells. In Vitro Toxicology 2:287-297.

Finch, G.L., A.L. Brooks, J.M. Benson, M.D. Hoover, A.F. Mewhinny, R.G. Edison, R.G. Cuddihy, R.F. Henderson, and C.H. Hobbs (1989) Influence of physiochemical properties of beryllium and nickel compounds on cultured cell toxicology. In: Effects of mineral dusts on cells, B.T. Mossman and R.O. Bergin (eds.). BIR Report 21, British Institute of Radiology, London, England, pp. 143-149.

Guilmette, R.A., Gillette, N.A., Eidson, A.F., Griffith, W.C., Brooks, A.L. (1989). Risks from radium and thorotrast, D.M. Taylor, C.W. Mays, G.B. Gerber and R.G. Thomas (eds.). British Institute of Radiology, London, pp. 125-128.

Guilmette, R.A., N.A. Gillett, A.F. Eidson, W.C. Griffith, and A.L. Brooks. (1989) The influence of nonuniform alpha irradiation of Chinese hamster liver on chromosome damage and the induction of cancer. In Risks from radium and thorotrast, D.M. Taylor, C.W. Mays, G.B. Gerber and R.G. Thomas (eds.). BIR Report 21, British Institute of Radiology, London, pp. 142-149.

Kelly, G., P.R. Kerkof, A.L. Brooks and P.J. Haley (1989) Oncogene activation in radiation-induced lung tumors. In Low dose; Radiation: Biological bases of risk assessment, K.F. Beverstock and J.W. Stather (eds.). Taylor and Francis, London, England, pp. 286-295.

Mauderly, J.L., W.E. Bechtold, J.A. Bond, A.L. Brooks, B.J. Chen, R.G. Cuddihy, J.R. Harkema, R.F. Henderson, N.F. Johnson, K. Rithidech, D.J. Thomasses (1989) Comparison of three methods of exposing rats to cigarette smoke. In Proceedings of a Symposium on Assessment of Inhalation Hazards: Integration and Extrapolation Using Diverse Data, Feb. 19-24, Hannover Germany. Exp. Pathol., pp. 194-197.

Rithidech, K., B.T. Chen, J.L. Mauderly, E.B. Whorton, Jr., and A.L. Brooks (1989) Cytogenetic effects of cigarette smoke on pulmonary alveolar macrophages of the rat. Environ. Mol. Mutagen. 14: 27-33.

Brooks, A.L., G.J. Newton, L.-J. Shyr, F.A. Seiler, and B.R. Scott (1990) The combined effects of alpha-particles and X-rays on cell killing and micronuclei induction in lung epithelial cells. Int. J. Radiat. Biol. 58, 799-811.

Brooks, A.L., Rithidech, K., Johnson, N.F., Thomassen, D.G., Newton, G.J. (1990) Evaluating chromosome damage to estimate dose to tracheal epithelial cells, In: Twenty-Ninth Hanford Life Sciences Symposium, Indoor radon and lung cancer: Reality or myth? Hanford Press, Richland WA. Part 2, pp. 601-614.

Finch, G.L., A.L. Brooks, J.M. Benson, M.D. Hoover, J.A. Mewhinney, A.F. Eidson, R.G. Cuddihy, R.F. Henderson, C.H. Hobbs (1990) Influence of physicochemical properties of beryllium and nickel compounds on cultured cell toxicity, NATO ASI Series, Vol. H30, Effects of mineral dusts on cells, B.T. Mossman and R.O. Begin (eds.). Springer-Verlag Berlin Heidelberg, pp. 85-92.

Hui, T.E., Brooks, A.L., Fisher, D.R., James, A.C., Jostes, R.F. (1990) Calculation of dose and hit probability to cells irradiated in vitro by alpha particles. PNL-SA-17741, 35th Annual Health Physics Society, Anaheim Calif.

Rithidech, K., J.A. Hotchkiss, W.C. Griffith, R.F. Henderson, and A.L. Brooks. (1990) Chromosome damage in rat pulmonary alveolar macrophages following ozone inhalation. Mutat. Res. 24:67-73.

Finch, G.L., W.T. Lowther, M.D. Hoover, A.L. Brooks (1991) Effects of Beryllium metal particles on the viability and function of cultlured rat alveolar macrophages. J. Toxicol. Environ. Health 34:103-114.

Benson, J.M., A.L. Brooks, R.F. Henderson (1992) Comparative in vitro cytotoxicity of nickel compounds to pulmonary alveolar macrophages and rat lung epithelial cells. In Nickel and human health: Current perspective, E. Nieboer and J.O. Nriagu (eds.). John Wiley and Sons, pp. 319-330.

Brooks, A.L., K.E. McDonald, B.B. Kimsey, R.M. Kitchin (1992) Radioadaptive response in vivo in Chinese hamsters injected with alpha-( 239Pu) or beta-gamma-(144Ce) emitting radionuclides, In. Low dose irradiation and biological defense mechanisms, T. Sugarara, L.A. Sagan and T. Aoyama (eds.). Elsevier Science Publishers, pp. 319-322.

Brooks, A.L., C.E. Mitchell, T. Lloyd, K.E. McDonald, N.F. Johnson (1992) Genotoxic effects of silicon carbide whiskers. Vitro Toxicology 5, 51-58.

Brooks, A.L., Kitchin, R.M., Johnson, N.F., Gilbert, E.S. (1992) The role of cellular and molecular studies in evaluation of health effects from combined radiation and chemical exposure. Radiat. Res. 113:121-122.

Brooks, A.L., Guilmette, R.A., Hahn, F.F., Haley, P.J., Muggenburg, B.A., Mewhinney J.A., McClellan, R.O. (1992) Distribution and biological effects of inhaled 239Pu(NO3)4 in cynomolgus monkeys. Radiat. Res. 130, 79-87.

Brooks, A.L., Rithidech, K., Johnson, N.F., Thomassen, D.G., Newton, G.J. (1992) Evaluating chromosome damage to estimate dose to tracheal epithelial cells. In: Twenty-Ninth Hanford Life Sciences Symposium, Indoor radon and lung cancer: Reality or myth? Battelle Press, Columbus, Richland, pp. 601-615.

Johnson, N.F., M.D. Hoover, D.G. Thomassen, Y.S. Cheng, A. Dalley, A.L. Brooks (1992) In vitro activity of silicon carbide whiskers in comparison to other industrial fibers using four cell culture systems. American J. of Ind. Hyg. 21, 807-823.

Brooks, A.L., R.F. Jostes, M.A. Khan, F.T. Cross (1993) Radon induced cytogenetic instability, Radiation Research Society 41st Annual meeting, Dallas, Texas, March 20-25 (Abstract #P-28-3).

Brooks, A.L., R.M. Kitchin, N.F. Johnson, E.S. Gilbert (1993) The role of cellular and molecular studies in evaluation of health effects from combined radiation and chemical exposures. Radiat. Res. 133, 121-122.

Brooks, A.L., M.A. Khan, R.F. Jostes, and F.T. Cross (1993) Metaphase chromosome aberrations as markers of radiation exposure and dose. J. Toxicol. Environ. Health 40, 227-288.

Brooks, A.L., M.A. Khan, R.F. Jostes, F.T. Cross (1993) Metaphase chromosome aberrations as markers of radiation exposure and dose. In: The laboratory and epidemiology: The developoment and application of biomarkers to the study of human health effects. L.E. Sever (ed.). Proceedings of the 31st Hanford Symposium on Health and the Environment, J. Toxicol Health 40:277-288.

Brooks, A.L., M.A. Khan, A. Duncan, R.L. Buschbom, R.F. Jostes, F.T. Cross (1994) Effectiveness of radon relative to acute 60Co gamma-rays for induction of micronuclei in vitro and in vivo. Int. J. Radiat. Biol. 66, 801-808.

Brooks, A.L., K.E. McDonald, C. Mitchell, G.E. Dagle, W.K. Yang (1994) Role of Pu induced chromosome alterations and mutated Ki-v-ras oncogene during liver cancer induction in Chinese hamsters and mice. In: Health effects of iInternally deposited radionuclides: Emphasis on radium and thorium, G. van Kaick, A. Karaoglou, A.M. Kellerer (eds.). World Scientific, Singapore, New Jersey, London, Hong Kong, pp. 397-402.

Brooks, A.L., McDonald, K.E., Mitchell, C., Dagle, G.E., Yang, W.K. (1995) Role of 239Pu induced chromosome alterations and mutated Ki-v-ras oncogene during liver cancer induction in Chinese hamsters and Mice. In Health effects of internally deposited radionuclides: Emphasis on radium and thorium, G. vanKaick, A. Karaoglou and A.M. Kellerer (eds.). World Scientific, Singapore, New Jersey, London, Hong Kong, pp. 397-402.

Adelstein, S.J., B.B. Boecker, B.J. McNeil, A.L. Brooks, R.E. Shore, K.R. Kase, W.L. Templeton, A. Kronenberg (1993) Research needs for radiation protection. Scientific Committee 83, NCRP Report No. 117, Issued Nov. 30, 1993, National Council on Radiation Protection and Measurements, Bethesda, MD.

Brooks, A.L., McDonald, K.E., Mitchell, C.E., Dagle, G.E., and Yang, W.K. (1994) Role of 239Pu induced chromosome alterations and mutated Ki-V-ras oncogene during liver-cancer induction in Chinese hamsters and mice In: International seminar health effects of internally deposited radionuclides, emphasis on radium, and thorium, Heidelburg, Germany. G. van Kaick and A.M. Keellerer (eds.). World Scientific, Singapore, New Jersey, London, Hong Kong, pp. 397-402.

Khan, M.A., F.T. Cross, R.F. Jostes, E. Hui, J.E. Morris, A.L. Brooks (1994) Micronuclei induced by radon and its progeny in deep-lung fibroblasts of rats in vivo and in vitro. Radiat. Res. 139, 53-59.

Khan, M.A., F.T. Cross, R.F. Jostes, A.L. Brooks (1994) Differences in radon-induced micronuclei between human bronchial epithelial cells and rat lung cells: In: Environmental mutagens and human health, Proceedings of the 18th annual Conference of the Environmental Mutagen Society of India, February 10-12, 1994, Madras, India.

Nelson, J.M., L.A. Braby, M.K. Lien, A.L. Brooks, M.A. Khan, M.E. Middendorf (1994) Radiation effects in single cells irradiated with individual charged particles. Cell Proliferation 27(7):413.

Braby, L.A., N.F. Metting, J.M. Nelson, A.L. Brooks (1995) Single particle microbeam irradiation of subcellular targets. Scanning Microscopy (Submitted).

Brooks, A.L., S. Bao, M.A. Khan, P.W. Harwood, B.H. Wood, W.B. Chrisler, K.M. Groch, F.T. Cross (1995) Use of cellular damage to determine the relationship between exposure and dose from inhaled radon, Pacific Northwest Association of Toxicologist, 12th Annual meeting, Sept. 15-16,1995, Moscow, ID (Abstract).

Brooks, A.L., R. Miick, R.L. Buschbom, M.K. Murphy, and M.A. Khan (1995) The role of dose rate on the induction of micronuclei in deep-lung fibroblasts in vivo after exposure to cobalt-60 gamma rays. Radiation Research 144:114-118

Brooks, A.L., R.E. Gephart, B.L. Harper, R.E. Lundgren, J.A. Mahaffey, M.J. Quadrel, W.G. Stillwell, (1995) Environmental decision making: The role of risk assessment, management and communication. B-TIP/Report No. 85.

Khan, M.A., F.T. Cross, R.L. Bushbom, A.L. Brooks (1995) Inhaled radon-induced genotoxicity in Wistar rat, Syrian hamster and Chinese hamster deep-lung fibroblasts in vivo. Mutat. Res. 334:131-137.

Brooks, A.L. (1996) Biodosimetry and molecular signatures, cellular changes. In: Radiation risk assessment, statistical methodology, and mechanisms, American Statistical Association Conference on Radiation and Health, Vail Colorado, 1996.

Brooks, A.L., K.E. McDonald, C. Mitchell, D.S. Culp, A. Lloyd, N.F. Johnson, R.M. Kitchin, (1996) Combined genotoxic effects of radiation and occupational pollutants. Applied Occupational and Environmental Hygiene 11(4):410-416.

Doctor, P.G., Brooks, A.L., Miley, T.B., Harper, B.L., Ivanovich, M.G., Quadrel, M.J., Thorsten, S.L. (1996) A risk assessment of indooor air pollution: Radon and tobacco smoke in North Dakota. Pacific Northwest National Laboratory, prepared for North Dakota Comparative Environmental Issues Project, Bismark, North Dakota.

Miller, R.C., Richards, M., Brenner, D.J., Hall, E.J., Jostes, R., Hui, E.E., and Brooks, A.L. (1996) The biological effectiveness of radon-progeny alpha particles, V. Oncogenic transformation from monoenergetic accelerator-produced alpha particles compared with polyenergetic alpha particles from radon porogeny. Radiat. Res. 146:75-80.

Nagarkatti, M., P.S. Nagarkatti, A.L. Brooks (1996) Effect of radon on the immune system: Alterations in the cellularity and functions of T cells in lymphoid organs of mouse. Journal of Toxicology and Environmental Health 47:535-545.

Nelson, J.M., A.L. Brooks, N.F. Metting, M.A. Khan, R.L. Buschbom, A. Duncan, R. Miick, L.A. Braby (1996) Clastogenic effects of defined numbers of 3.2 MeV alpha particles on individual CHO-K1 cells. Radiat. Res. 145:568-574.

Rithidech, K., V.P. Bond, E.P. Cronkite, A.L. Brooks (1996) Karyotypic evolution during tumor progression. Int. J. Radiat. Biol. 68(3):348.

Bao, S., P.W. Harwood, W.B. Chrisler, K.M. Groch, A.L. Brooks (1997) Comparative clastogenic sensitivity of respiratory tract cells to gamma rays. Radiat. Res. 148:90-97.

Brooks, A.L., S. Bao, P.W. Harwood, B.H. Wood, W.B. Chrisler, R.A. Gies, F.T. Cross (1997) Induction of micronuclei in respiratory tract following radon inhalation. Inter. J. Radiat. Biol. 72(5):485-495.

Groch, K.M., M.A. Khan, A.L. Brooks, J.D. Saffer (1997) Lung cancer response following inhaled radon by the A/J and C57BL/6J mouse. International Journal of Radiation Biology 71(3):301-308.

Brooks A.L. (1998) Chromosome aberrations, Encyclopedia of toxicology, Vol. 1, Editor-in-Chief Philip Wexler, Academic Press, pp. 136-138.

Samet, J.M., D. Brenner, A.L. Brooks, W.H. Ellett, E.S. Gilbert, D.T. Goodhead, E.J. Hall, P.K. Hopke, D. Krewski, J.H. Lubin, R.O. McClellan, P.L. Ziemer (1999) Health effects of exposure to radon (BEIR VI). Committee on Health Risks of Exposure to Radon, Board on Radiation Effects Research, Commission on Life Sciences, National Research Council, National Academy Press, Washington D.C.

Brooks, A.L. (1999) Dosimetry at low dose rates: Biological and molecular approaches. Radiation Research 151:109-110.

Brooks, A.L. (1999) Biomarkers of exposure, sensitivity and disease. International Journal of Radiation Biology 75(2):1481-1503.

Brooks, A.L., M.A. Khan, S. Bao, L.A. Braby, N.F. Johnson, F.T. Cross (1999) Radon induced micronulcei in respiratory tract biodosimetry. In: Indoor radon and its health consequences: Quest for the true story of environmental radon and lung cancer, J. Inaba, H. Yonehara, M. Doi (eds.). Kodanshi Scientific LTD, pp. 67-82.

Brooks, A.L. (2000) The potential impact of cellular and molecular biology on radiation risk assessment, Technology 7, Topical issue honoring Merril Eisenbud, pp. 251-263.

Brooks, A.L. (2000) The evaluation of disease risk (Discussion). Radiat. Res. 154(6):726-727.

Brooks, A.L., E.E. Hui, V.P. Bond (2000) Energy barriers for radiation-induced cellular effects. In: Biological effects of low dose radiation. T. Yamada (ed.). Elsevier Science, pp. 19-27.

Rithidech, K., Thomassen, D.G., Kelly, G., Johnson, N.F., Brooks, A.L. (submitted) Karyotypic evolution during tumor progression in rat tracheal epithelial cells treated with N-methyl-N'-nitro-N-nitrosoguanidine, Submitted (Carcinogenesis).

Brooks, A.L. (2001) Biomarkers of exposure and dose: State of the art. Radiat. Prot. Dosi. 97:39-46.

A.L. Brooks, S. Bao, K. Rithidech, W.B. Chrisler, L.A. Couch, L.A. Braby (2001) Induction and repair of HZE induced cytogenetic damage. Physica Medica XVII, Supplement 1:1-2.

Brooks, A.L., S. Bao, K. Rithidech, L.A. Couch, L.A. Braby (2001) Relative effectiveness of HZE Iron-56 particles for the induction of cytogenetic damage in vivo. Radiat. Res. 155:353-359.

Brooks, A.L., Taylor, G.N., Benjamin, S. Wegener, K., van Kaick, G., Wesch, H. (2001) Liver cancer risk from internally-deposited radionuclides. National Council on Radiation Protection and Measurements, Bethesda, MD, 20814. NCRP Report No. 135.

Barcellos-Hoff, M.H., A.L. Brooks (2001) Extracellular signaling through the microenvrionment: A hypothesis relating carcinogenesis, bystander effects and genomic instability. Radiat. Res. 156: 618-627.

Blakely, W.F., A.L. Brooks, R.S. Lofts, G.P. van der Schans, P. Voisin (2002) Overview of low-level radiation exposure assessment: Biodosimetry. Military Medicine 167:20-25.

Brooks, A.L. (2003) Developing a scientific basis for radiation risk estimates: major goal of the DOE Low Dose Radiation Research Program. In: Radiation and Humankind International Congress Series 1258,287-295.

Brooks, A.L. (2003) Developing a scientific basis for radiation risk estimates: Goal of the DOE Low Dose Radiation Research Program. Health Physics 85(1):85-102.

Brooks, A.L., Lei, X.C., and Rithidech, K. (2003) Changes in biomarkers from space radiation my reflect dose not risk. Adv. Space Res. 31(6): 1505-1512.

Brooks, A.L. (2004) Evidence for "bystander effects" in vivo. Human & Experimental Toxicology 23:67-70.

Brooks, A.L., (2004) The LNTH is doing more harm than good: Reply to Tschaeche. Health Physics 86(1):92-93.

Brooks, A.L., Couch, L. (2004) DOE Program - Developing a scientific basis for responses to low-dose exposures: Impact on dose-response relationships, The 14th Pacific Basin Nuclear Conference, Honolulu, Hawaii.

Brooks, A.L. (2005) Comments of the article, “Possible contribution of ¹²⁹I in the drinking water and food supply to the nodular formation of thyroid tissue.” Health Physics 89(3):274.

Brooks , A.L. (2005) Chromosome aberrations. Encyclopedia of Toxicology, Academic Press. 1:606-607.

Brooks, A.J. (2005) From cell to organism: The need for multiparametric assessment of exposure and biological effects. The British J. of Radiology 78:1-7.

Brooks, A.L. (2005) Paradigm shifts in radiation biology: Their impact on intervention for radiation-induced disease. Radiation Research 164:454-461.

Bond, V.P., Sondhaus, C.A., Couch, L.A., Brooks, A.L. (2005) “The requirement for Energy Imparted in Radiation Protection Practice” International Journal of Low Radiation 1(4):452-462.

Brooks, A.L. (2006) Where have all the Thresholds Gone? In: Chapter 10 Biological Effects of Low Doses of Ionizing Radiation, Advances in Medical Physics Volume 1 2006 edt: Anthony Brinton Wolbarst, Robert Zamenhof, William Hendee (In press)