JESS seminar, Amphibian Metamorphosis, 12 p.m., East Auditorium
Nutritional Regulation of Early Development: Novel Roles of Leptin in Amphibian Metamorphosis.
Seminar presented by Dr. Erica Crespi, Assistant Professor in the School of Biological Sciences at Washington State University
Leptin is a hormone secreted by fat that has been largely studied for its role in appetite and energy balance regulation, however, the study of leptin in amphibians has led to a greater understanding of its role as a modulator of early developmental processes. The initial characterization of leptin function in amphibians revealed that treatment with recombinant Xenopus leptin protein accelerated limb growth and development in early prometamorphic tadpoles, suggesting a role as a growth factor during tadpole stages. Subsequent studies in Xenopus laevis support this hypothesis, as leptin treatment accelerates limb development and growth in part by increasing cell proliferation. This talk will focus on what my research lab has learned about the roles of leptin in limb development and regeneration, establishing for the first time a role for leptin in morphogenesis in vertebrates. Given that leptin expression is positively correlated with nutritional state at this stage of tadpole development, it may serve as a link between nutrition and early developmental processes.
The Joint Engineering and Science Seminar (JESS) series is an interdisciplinary effort of the College of Arts and Sciences and the Office of Professional Programs at WSU Tri-Cities. Admission is free and open to the public; graduate students, post-docs and professionals are especially encouraged to attend.
For more information, contact:
Dr. Yonas Demissie
Assistant Professor of Civil & Environmental Engineering
Nikolaos Voulgarakis, Ph.D.
Assistant Professor of Mathematics